Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells.

@article{Tanaka2004InterplayOS,
  title={Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells.},
  author={Shinya Tanaka and Yusuke Kamachi and Aki Tanouchi and Hiroshi Hamada and Naihe Jing and Hisato Kondoh},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 20},
  pages={8834-46}
}
Intermediate-filament Nestin and group B1 SOX transcription factors (SOX1/2/3) are often employed as markers for neural primordium, suggesting their regulatory link. We have identified adjacent and essential SOX and POU factor binding sites in the Nestin neural enhancer. The 30-bp sequence of the enhancer including these sites (Nes30) showed a nervous system-specific and SOX-POU-dependent enhancer activity in multimeric forms in transfection assays and was utilized in assessing the specificity… CONTINUE READING
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Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex

  • D. C. Williams, Jr., M. Cai, G. M. Clore
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