Interplay of Gene Expression Noise and Ultrasensitive Dynamics Affects Bacterial Operon Organization

@inproceedings{Ray2012InterplayOG,
  title={Interplay of Gene Expression Noise and Ultrasensitive Dynamics Affects Bacterial Operon Organization},
  author={J. Christian J. Ray and Oleg A. Igoshin},
  booktitle={PLoS Computational Biology},
  year={2012}
}
Bacterial chromosomes are organized into polycistronic cotranscribed operons, but the evolutionary pressures maintaining them are unclear. We hypothesized that operons alter gene expression noise characteristics, resulting in selection for or against maintaining operons depending on network architecture. Mathematical models for 6 functional classes of network modules showed that three classes exhibited decreased noise and 3 exhibited increased noise with same-operon cotranscription of… CONTINUE READING

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