Interplay between type 1A topoisomerases and gyrase in chromosome segregation in Escherichia coli.

@article{Usongo2013InterplayBT,
  title={Interplay between type 1A topoisomerases and gyrase in chromosome segregation in Escherichia coli.},
  author={Valentine Usongo and Cynthia Tanguay and Flora Nolent and Jill Egbe Bessong and Marc Drolet},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 8},
  pages={
          1758-68
        }
}
Escherichia coli possesses two type 1A topoisomerases, Topo I (topA) and Topo III (topB). Topo I relaxes excess negative supercoiling, and topA mutants can grow only in the presence of compensatory mechanisms, such as gyrase mutations. topB mutants grow as well as wild-type cells. In vitro, Topo III, but not Topo I, can efficiently decatenate DNA during replication. However, in vivo, a chromosome segregation defect is seen only when both type 1A topoisomerases are absent. Here we present… CONTINUE READING
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