Interplay between the tumor suppressor p53 and TGF beta signaling shapes embryonic body axes in Xenopus.

@article{TakebayashiSuzuki2003InterplayBT,
  title={Interplay between the tumor suppressor p53 and TGF beta signaling shapes embryonic body axes in Xenopus.},
  author={Kimiko Takebayashi-Suzuki and Jun Funami and Daisuke Tokumori and Akira Saito and Tetsuro Watabe and Kohei Miyazono and Akifumi Kanda and Atsushi Suzuki},
  journal={Development},
  year={2003},
  volume={130 17},
  pages={3929-39}
}
The transcription factor p53 has been shown to mediate cellular responses to diverse stresses such as DNA damage. However, the function of p53 in cellular differentiation in response to growth factor stimulations has remained obscure. We present evidence that p53 regulates cellular differentiation by modulating signaling of the TGF beta family of growth factors during early Xenopus embryogenesis. We show that p53 functionally and physically interacts with the activin and bone morphogenetic… CONTINUE READING