Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells

@article{Jiang2007InterplayBT,
  title={Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells},
  author={Xiao-hua Jiang and Stephanie J. H. Ellison and Elaine T. Alarid and David J. Shapiro},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={4106-4114}
}
Estrogens promote cell proliferation and metastases in several human cancers. Here, we describe a different action of estrogens likely to contribute to tumor development-blocking immunosurveillance. In breast cancer cells, increasing concentrations of estrogen induce increasing levels of the granzyme B inhibitor, SerpinB9/proteinase inhibitor 9 (PI-9) and progressively block cell death induced by NK92 natural killer (NK) cells, but do not block killing by a second NK cell line, NKL cells. RNA… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma

  • I van Houdt, JJ Oudejans, AJ van den Eertwegh, A Baars, W Vos, BA Bladergroen
  • Clin Cancer Res
  • 2005
Highly Influential
2 Excerpts

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

  • J. Lieberman
  • Nat Rev Immunol
  • 2003
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…