Interplay between the folding mechanism and binding modes in folding coupled to binding processes.

Abstract

Proteins that fold upon binding to their partners exhibit complex binding behavior such as induced-fit. But the connections between the folding mechanism and the binding mode remain unknown. Here we focus on the high affinity complex between the physiologically and marginally unstable, fast folder PSBD and the E1 subunit of pyruvate dehydrogenase. Using… (More)
DOI: 10.1039/c7cp04748g

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