Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair.

@article{Chen2009InterplayBT,
  title={Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair.},
  author={Yu-hung Chen and Koyi Choi and Barnabas Szakal and Jacqueline Arenz and Xinyuan Duan and Hong Ye and Dana Branzei and Xiaolan Zhao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 50},
  pages={21252-7}
}
The evolutionarily conserved Smc5/6 complex is implicated in recombinational repair, but its function in this process has been elusive. Here we report that the budding yeast Smc5/6 complex directly binds to the DNA helicase Mph1. Mph1 and its helicase activity define a replication-associated recombination subpathway. We show that this pathway is toxic when the Smc5/6 complex is defective, because mph1Delta and its helicase mutations suppress multiple defects in mutants of the Smc5/6 complex… CONTINUE READING