Interplay between rolling and firm adhesion elucidated with a cell-free system engineered with two distinct receptor-ligand pairs.

@article{Eniola2003InterplayBR,
  title={Interplay between rolling and firm adhesion elucidated with a cell-free system engineered with two distinct receptor-ligand pairs.},
  author={A O A Omolola Eniola and P Jeanene Willcox and Daniel A. Hammer},
  journal={Biophysical journal},
  year={2003},
  volume={85 4},
  pages={2720-31}
}
The firm arrest of leukocytes to the endothelium during inflammation is known to be mediated by endothelial intercellular adhesion molecules (ICAMs) binding to activated integrins displayed on leukocyte surface. Selectin-ligand interactions, which mediate rolling, are believed to be important for facilitating firm adhesion, either by activating integrins or by facilitating the transition to firm adhesion by making it easier for integrins to bind. Although leukocytes employ two distinct adhesion… CONTINUE READING

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