Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

@article{Micco2011InterplayBO,
  title={Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer},
  author={Raffaella Di Micco and Gabriele Sulli and Miryana Dobreva and Michalis Liontos and Oronza Antonietta Botrugno and Gaetano Gargiulo and Roberto dal Zuffo and Valentina Matti and Giovanni d'Ario and Erica Montani and Ciro Mercurio and William C. Hahn and Vassilis G Gorgoulis and Saverio Minucci and Fabrizio d'Adda di Fagagna},
  journal={Nature Cell Biology},
  year={2011},
  volume={13},
  pages={292-302}
}
Two major mechanisms have been causally implicated in the establishment of cellular senescence: the activation of the DNA damage response (DDR) pathway and the formation of senescence-associated heterochromatic foci (SAHF). Here we show that in human fibroblasts resistant to premature p16INK4a induction, SAHF are preferentially formed following oncogene activation but are not detected during replicative cellular senescence or on exposure to a variety of senescence-inducing stimuli. Oncogene… CONTINUE READING
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