Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

  title={Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer},
  author={Raffaella Di Micco and Gabriele Sulli and Miryana Dobreva and Michalis Liontos and Oronza Antonietta Botrugno and Gaetano Gargiulo and Roberto dal Zuffo and Valentina Matti and Giovanni d'Ario and Erica Montani and Ciro Mercurio and William C. Hahn and Vassilis G Gorgoulis and Saverio Minucci and Fabrizio d'Adda di Fagagna},
  journal={Nature Cell Biology},
Two major mechanisms have been causally implicated in the establishment of cellular senescence: the activation of the DNA damage response (DDR) pathway and the formation of senescence-associated heterochromatic foci (SAHF). Here we show that in human fibroblasts resistant to premature p16INK4a induction, SAHF are preferentially formed following oncogene activation but are not detected during replicative cellular senescence or on exposure to a variety of senescence-inducing stimuli. Oncogene… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.


Publications referenced by this paper.
Showing 1-10 of 62 references

a general phenomenon? J

I. A. Kim, I. H. Kim, +3 authors J. S. HDAC inhibitor-mediated radiosensitization in h cells
Radiat. Res. (Tokyo) 51, 257–263 • 2010

evidence from mice and humans

M. Collado, Serrano, M. Senescence in tumours
Nat. Rev. Cancer 10, 51–57 • 2010

Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas

M Liontos
Am. J. Pathol • 2009

a discovery tool for the analysis of chromatin structure and dynamics during differentiation

Gargiulo, G. et al. NA-Seq
Dev. Cell 16, 466–481 • 2009

a hallmark of cell proliferation relevant to clinical oncology

De Koning, L. et al. Heterochromatin protein 1α
EMBO Mol. Med. 1, 13 • 2009

molecular mechanisms, functions and pathologies of cellular senescence

Adams, P. D. Healing, hurting
Mol. Cell 36, 2–14 • 2009

Similar Papers

Loading similar papers…