Interplay between mitochondria and cellular calcium signalling

  title={Interplay between mitochondria and cellular calcium signalling},
  author={Jake H Jacobson and Michael R Duchen},
  journal={Molecular and Cellular Biochemistry},
Mitochondria are increasingly ascribed central roles in vital cell signalling cascades. These organelles are now recognised as initiators and transducers of a range of cell signals, including those central to activation and amplification of apoptotic cell death. Moreover, as the main source of cellular ATP, mitochondria must be responsive to fluctuating energy demands of the cell. As local and global fluctuations in calcium concentration are ubiquitous in eukaryotic cells and are the common… CONTINUE READING