Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons

@inproceedings{Castillo2015InterplayBK,
  title={Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons},
  author={Urko del Castillo and Michael Winding and Wen Lu and Vladimir I Gelfand and Victoria J Allan},
  booktitle={eLife},
  year={2015}
}
In this study, we investigated how microtubule motors organize microtubules in Drosophila neurons. We showed that, during the initial stages of axon outgrowth, microtubules display mixed polarity and minus-end-out microtubules push the tip of the axon, consistent with kinesin-1 driving outgrowth by sliding antiparallel microtubules. At later stages, the microtubule orientation in the axon switches from mixed to uniform polarity with plus-end-out. Dynein knockdown prevents this rearrangement and… CONTINUE READING
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Developmental Cell 28:295–309

AL Jolly, H Kim, +3 authors VI. Gelfand
2010
View 7 Excerpts
Highly Influenced

GFP (end-binding protein 3-green fluorescent protein)

MC Stone, F Roegiers, MM. Rolls
Journal of Neuroscience • 2008
View 5 Excerpts
Highly Influenced

The EMBO Journal 22:6004–6015

K Jaqaman, D Loerke, +4 authors G. Danuser
2008
View 2 Excerpts
Highly Influenced

microtubules. Cell 75:419–429

VC Nadar, A Ketschek, KA Myers, G Gallo, PW. Baas
2008
View 2 Excerpts
Highly Influenced

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