Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.

@article{Soosairajah2005InterplayBC,
  title={Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.},
  author={Juliana Soosairajah and Sankar Maiti and O'neil Wiggan and Patrick D Sarmiere and Nathalie Moussi and Boris Sarcevic and Rashmi Sampath and James R. Bamburg and Ora Bernard},
  journal={The EMBO journal},
  year={2005},
  volume={24 3},
  pages={473-86}
}
Slingshot (SSH) phosphatases and LIM kinases (LIMK) regulate actin dynamics via a reversible phosphorylation (inactivation) of serine 3 in actin-depolymerizing factor (ADF) and cofilin. Here we demonstrate that a multi-protein complex consisting of SSH-1L, LIMK1, actin, and the scaffolding protein, 14-3-3zeta, is involved, along with the kinase, PAK4, in the regulation of ADF/cofilin activity. Endogenous LIMK1 and SSH-1L interact in vitro and co-localize in vivo, and this interaction results in… CONTINUE READING
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