Corpus ID: 42102302

Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa.

@article{Masuda1999InterplayBC,
  title={Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa.},
  author={Nobuhisa Masuda and Naomasa Gotoh and C Ishii and Eiko Sakagawa and Satoshi Ohya and Takeshi Nishino},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 2},
  pages={
          400-2
        }
}
We investigated the role of chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa. Determination of the susceptibilities of a series of isogenic mutants with impaired production of the beta-lactamase and the efflux system to 16 beta-lactams including penicillins, cephems, oxacephems, carbapenems, and a monobactam demonstrated that the intrinsic resistance of P. aeruginosa to most of the beta-lactams is due to the interplay… Expand
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