Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis.

@article{Jiang2008InterplayBB,
  title={Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis.},
  author={Jianfei Jiang and Zhentai Huang and Qing Zhao and Weihong Feng and Natalia A. Belikova and Valerian E Kagan},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={368 1},
  pages={145-50}
}
Bax/Bak activation and cardiolipin peroxidation are essential for cytochrome c release during apoptosis, yet, the link between them remains elusive. We report that sequence of events after exposure of mouse embryonic fibroblast (MEF) cells to actinomycin D followed the order: Bax translocation-->superoxide production-->cardiolipin peroxidation. Genetic ablation of Bax/Bak inhibited actinomycin D induced superoxide production and cardiolipin peroxidation. Rotenone caused robust superoxide… CONTINUE READING

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