Interplay between axonal Wnt5-Vang and dendritic Wnt5-Drl/Ryk signaling controls glomerular patterning in the Drosophila antennal lobe

  title={Interplay between axonal Wnt5-Vang and dendritic Wnt5-Drl/Ryk signaling controls glomerular patterning in the Drosophila antennal lobe},
  author={Huey Hing and Noah Reger and Jennifer Snyder and Lee G. Fradkin},
  journal={PLoS Genetics},
Despite the importance of dendritic targeting in neural circuit assembly, the mechanisms by which it is controlled still remain incompletely understood. We previously showed that in the developing Drosophila antennal lobe, the Wnt5 protein forms a gradient that directs the ~45˚ rotation of a cluster of projection neuron (PN) dendrites, including the adjacent DA1 and VA1d dendrites. We report here that the Van Gogh (Vang) transmembrane planar cell polarity (PCP) protein is required for the… Expand
2 Citations
RYK-mediated filopodial pathfinding facilitates midgut elongation
It is revealed that the ligand-receptor pair WNT5A-RYK acts as a navigation system to instruct filopodial pathfinding, a process that is crucial for continuous cell cycling to fuel rapid midgut elongation. Expand
Extrinsic Factors Regulating Dendritic Patterning
This review focuses on the actions of extrinsic intercellular communication factors and their effects on intrinsic developmental processes that lead to dendrite patterning, and how the coordinated signaling of multiple extrinsical factors promotes complexity in dendritic trees and ensures robust dendrites patterning. Expand


Wnt5 and Drl/Ryk Gradients Pattern the Drosophila Olfactory Dendritic Map
It is proposed that Wnt5 acts as a repulsive guidance cue for the PN dendrites, whereas Drl signaling in the dendrite inhibits Wnt 5 signaling, and the precise expression patterns ofWnt5 and Drl orient the Pn dendritic positions allowing them to target their final glomerular positions. Expand
Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.
It is proposed that the antagonistic functions of Vangl2 and Dvl1 (over Frizzled3 hyperphosphorylation and endocytosis) allow sharpening of PCP signaling locally on the tips of the filopodia to sense directional cues, Wnts, eventually causing turning of growth cones. Expand
Adult Drosophila sensory neurons specify dendritic territories independently of dendritic contacts through the Wnt5-Drl signaling pathway.
Adult C4da neurons rely on both dendritic repulsive interactions and external positional cues to delimit the boundaries of their dendrite fields, and the discovery of Wnt5 derived from sternites is identified as the critical determinant for the ventral boundaries. Expand
Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors.
The biochemical data support the existence of a ternary complex composed of the cleaved DRL ectodomain, WNT5, and DRL-2, and the interaction of MB-extrinsic and -intrinsics Ryks via their common ligand acts to guide MB α axons. Expand
Antagonistic roles of Wnt5 and the Drl receptor in patterning the Drosophila antennal lobe
The findings establish wnt5 as an anterograde signal that is expressed by olfactory axons and demonstrate a previously unappreciated, yet powerful, role for glia in patterning the Drosophila Olfactory map. Expand
The Wnt5/Planar Cell Polarity Pathway Regulates Axonal Development of the Drosophila Mushroom Body Neuron
Axonal development is a fundamental process for circuit formation in the nervous system and is dependent on many cellular events, including axon initiation, elongation, guidance, and branching. TheExpand
The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila
It is proposed that the Wnt5/PCP navigation system is linked by dDAAM to the regulation of the growth cone actin cytoskeleton, and thereby growth cone behavior, in a direct way. Expand
The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling*
The data suggest an important role for Ryk in Wnt/planar cell polarity signaling during vertebrate development via the Vangl2 signaling pathway, as demonstrated in the mouse cochlea. Expand
The Wnt Coreceptor Ryk Regulates Wnt/Planar Cell Polarity by Modulating the Degradation of the Core Planar Cell Polarity Component Vangl2*
It is found that the receptor-like tyrosine kinase (Ryk), a Wnt5a-binding protein required in axon guidance, regulates PCP signaling and is identified as a general regulator of the mammalian Wnt/PCP signaling pathway. Expand
Differentially Expressed Drl and Drl-2 Play Opposing Roles in Wnt5 Signaling during Drosophila Olfactory System Development
The genetic data suggest that Drl localized to developing glomeruli mediates Wnt5 signaling, and these two members of the Ryk family are capable of carrying out a similar molecular function, but they can play opposing roles in Wnt 5 signaling, depending on the type of cells in which they are expressed. Expand