Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions.

@article{Chen2016InterplayBT,
  title={Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions.},
  author={Zhangguo Chen and Maxwell D. Eder and Mihret T. Elos and Sawanee S. Viboolsittiseri and Xiaomi Chen and Jing Wang},
  journal={Journal of immunology},
  year={2016},
  volume={196 5},
  pages={2335-47}
}
Activation-induced deaminase (AID) functions by deaminating cytosines and causing U:G mismatches, a rate-limiting step of Ab gene diversification. However, precise mechanisms regulating AID deamination frequency remain incompletely understood. Moreover, it is not known whether different sequence contexts influence the preferential access of mismatch repair or uracil glycosylase (UNG) to AID-initiated U:G mismatches. In this study, we employed two knock-in models to directly compare the… CONTINUE READING

From This Paper

Topics from this paper.
1 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…