Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.

@article{Ngo2005InterplayBS,
  title={Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.},
  author={Jacky Chi Ki Ngo and Sutapa Chakrabarti and Jian-hua Ding and Adolfo L Velazquez-Dones and Brad J. Nolen and Brandon E. Aubol and Joseph A. Adams and Xiang-Dong Fu and Gourisankar Ghosh},
  journal={Molecular cell},
  year={2005},
  volume={20 1},
  pages={77-89}
}
The arginine-serine (RS)-rich domain of the SR protein ASF/SF2 is phosphorylated by SR protein kinases (SRPKs) and Clk/Sty kinases. However, the mode of phosphorylation by these kinases and their coordination in the biological regulation of ASF/SF2 is unknown. Here, we report the crystal structure of an active fragment of human SRPK1 bound to a peptide derived from an SR protein. This structure led us to identify a docking motif in ASF/SF2. We find that this docking motif restricts… CONTINUE READING
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