Interplay between NO and [Fe-S] clusters: relevance to biological systems.

  title={Interplay between NO and [Fe-S] clusters: relevance to biological systems.},
  author={Jean Claude Drapier},
  volume={11 3},
In mammalian cells, nitric oxide (NO) synthesis results in the inactivation of several mitochondrial iron-sulfur enzymes involved in ATP synthesis that correlates with the appearance of complexes of the [(NO)2Fe(SR)2] type detectable by electron paramagnetic resonance spectroscopy. More specifically, the activity of two [Fe-S] enzymes was followed during the course of NO synthase expression:mitochondrial aconitase, which catalyzes citrate:isocitrate conversion in the Krebs cycle, and… CONTINUE READING
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