Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.

@article{Drouet2006InterplayBK,
  title={Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.},
  author={J{\'e}r{\^o}me Drouet and Philippe Frit and Christine Delteil and Jean-Pierre de Villartay and Bernard Salles and Patrick Calsou},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 38},
  pages={27784-93}
}
Repair of DNA double strand breaks (DSB) by the nonhomologous end-joining pathway in mammals requires at least seven proteins involved in a simplified two-step process: (i) recognition and synapsis of the DNA ends dependent on the DNA-dependent protein kinase (DNA-PK) formed by the Ku70/Ku80 heterodimer and the catalytic subunit DNA-PKcs in association with Artemis; (ii) ligation dependent on the DNA ligase IV.XRCC4.Cernunnos-XLF complex. The Artemis protein exhibits exonuclease and… CONTINUE READING