Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.

@article{McLoughlin2003InterplayBI,
  title={Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.},
  author={Rachel M McLoughlin and Janusz Witowski and Rachel L. Robson and Thomas S. Wilkinson and Suzanne M. Hurst and Anwen Si{\^a}n Williams and John David Williams and Stefan Rose-John and Simon A Jones and Nicholas Topley},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 4},
  pages={598-607}
}
Regulated recruitment and clearance of neutrophils (PMN) is the hallmark of competent host defense and resolution of inflammation. We now report that IFN-gamma controls PMN infiltration and modulates IL-6 signaling through its soluble receptor (sIL-6R) to promote their apoptosis and clearance. Induction of peritoneal inflammation in IFN-gamma-deficient (IFN-gamma-/-) mice emphasized that the initial rate of PMN recruitment was impaired. This defect in PMN recruitment was also associated with… CONTINUE READING
107 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 107 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo

  • Robson, R.L
  • J. Immunol
  • 2001

Similar Papers

Loading similar papers…