Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation.

  title={Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation.},
  author={Nadine Martin and Nikolay L Popov and Francesca Aguil{\'o} and Ana O'Loghlen and Selina Raguz and Ambrosius P Snijders and Gopuraja Dharmalingam and Side Li and Efstathia Thymiakou and Thomas Carroll and Bernd B. Zeisig and Chi Wai Eric So and Gordon G Peters and Vasso Episkopou and Martin J. Walsh and Jes{\'u}s Gil},
  journal={The EMBO journal},
  volume={32 7},
The INK4/ARF locus regulates senescence and is frequently altered in cancer. In normal cells, the INK4/ARF locus is found silenced by Polycomb repressive complexes (PRCs). Which are the mechanisms responsible for the recruitment of PRCs to INK4/ARF and their other target genes remains unclear. In a genetic screen for transcription factors regulating senescence, we identified the homeodomain-containing protein HLX1 (H2.0-like homeobox 1). Expression of HLX1 extends cellular lifespan and blunts… CONTINUE READING
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