Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition.

@article{Wu2011InterplayBH,
  title={Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition.},
  author={Min-Zu Wu and Ya-Ping Tsai and Muh-Hwa Yang and Chi-Hung Huang and S. -J. Chang and Cheng-Chi Chang and S K Teng and Kou-Juey Wu},
  journal={Molecular cell},
  year={2011},
  volume={43 5},
  pages={811-22}
}
Epithelial-mesenchymal transition (EMT) is important for organ development, metastasis, cancer stemness, and organ fibrosis. Molecular mechanisms to coordinately regulate hypoxia-induced EMT remain elusive. Here, we show that HIF-1α-induced histone deacetylase 3 (hdac3) is essential for hypoxia-induced EMT and metastatic phenotypes. Change of specific chromatin states is associated with hypoxia-induced EMT. Under hypoxia, HDAC3 interacts with hypoxia-induced WDR5, recruits the histone… CONTINUE READING
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The role of chromatin during transcription

  • B. Li, M. Carey, J. L. andWorkman
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