Interplay between DNA repair and inflammation, and the link to cancer.

  title={Interplay between DNA repair and inflammation, and the link to cancer.},
  author={Dawit Kidane and Wook Jin Chae and Jennifer R. Czochor and K. A. Eckert and Peter M. Glazer and Alfred L. M. Bothwell and Joann Balazs Sweasy},
  journal={Critical reviews in biochemistry and molecular biology},
  volume={49 2},
DNA damage and repair are linked to cancer. DNA damage that is induced endogenously or from exogenous sources has the potential to result in mutations and genomic instability if not properly repaired, eventually leading to cancer. Inflammation is also linked to cancer. Reactive oxygen and nitrogen species (RONs) produced by inflammatory cells at sites of infection can induce DNA damage. RONs can also amplify inflammatory responses, leading to increased DNA damage. Here, we focus on the links… CONTINUE READING
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