Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development.

@article{Ikegami2009InterplayBD,
  title={Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development.},
  author={Kohta Ikegami and Jun Ohgane and Satoshi Tanaka and Shintaro Yagi and Kunio Shiota},
  journal={The International journal of developmental biology},
  year={2009},
  volume={53 2-3},
  pages={203-14}
}
Genes constitute only a small proportion of the mammalian genome, the majority of which is composed of non-genic repetitive elements including interspersed repeats and satellites. A unique feature of the mammalian genome is that there are numerous tissue-dependent, differentially methylated regions (T-DMRs) in the non-repetitive sequences, which include genes and their regulatory elements. The epigenetic status of T-DMRs varies from that of repetitive elements and constitutes the DNA… CONTINUE READING
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