Interplay between Chromosomal β-Lactamase and the MexAB-OprM Efflux System in Intrinsic Resistance to β-Lactams inPseudomonas aeruginosa

@article{Masuda1999InterplayBC,
  title={Interplay between Chromosomal $\beta$-Lactamase and the MexAB-OprM Efflux System in Intrinsic Resistance to $\beta$-Lactams inPseudomonas aeruginosa},
  author={Nobuhisa Masuda and Naomasa Gotoh and C Ishii and Eiko Sakagawa and Satoshi Ohya and Takeshi Nishino},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1999},
  volume={43},
  pages={400 - 402}
}
ABSTRACT We investigated the role of chromosomal β-lactamase and the MexAB-OprM efflux system in intrinsic resistance to β-lactams inPseudomonas aeruginosa. Determination of the susceptibilities of a series of isogenic mutants with impaired production of the β-lactamase and the efflux system to 16 β-lactams including penicillins, cephems, oxacephems, carbapenems, and a monobactam demonstrated that the intrinsic resistance of P. aeruginosa to most of the β-lactams is due to the interplay of both… Expand
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