Interplay between Ca2+ cycling and mitochondrial permeability transition pores promotes reperfusion-induced injury of cardiac myocytes

@inproceedings{Abdallah2011InterplayBC,
  title={Interplay between Ca2+ cycling and mitochondrial permeability transition pores promotes reperfusion-induced injury of cardiac myocytes},
  author={Y. A. G. Abdallah and Sascha Andreas Kasseckert and Wisam Iraqi and Maher Said and Tayyab Shahzad and Ali Yasin Erdogan and Christiane Neuhof and D{\"u}rs{\"u}n G{\"u}nd{\"u}z and K. -D. Schl{\"u}ter and Harald Tillmanns and Hans Michael Piper and Hans Peter Reusch and Yury Ladilov},
  booktitle={Journal of cellular and molecular medicine},
  year={2011}
}
Uncontrolled release of Ca(2+) from the sarcoplasmic reticulum (SR) contributes to the reperfusion-induced cardiomyocyte injury, e.g. hypercontracture and necrosis. To find out the underlying cellular mechanisms of this phenomenon, we investigated whether the opening of mitochondrial permeability transition pores (MPTP), resulting in ATP depletion and reactive oxygen species (ROS) formation, may be involved. For this purpose, isolated cardiac myocytes from adult rats were subjected to simulated… CONTINUE READING
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