Interplay among membrane properties, protein properties and operating conditions on protein fouling during normal-flow microfiltration

@article{Loh2009InterplayAM,
  title={Interplay among membrane properties, protein properties and operating conditions on protein fouling during normal-flow microfiltration},
  author={ShyTyug Loh and U. Beuscher and Tarun Poddar and Andrew J. Porter and J. Wingard and S. Husson and S. R. Wickramasinghe},
  journal={Journal of Membrane Science},
  year={2009},
  volume={332},
  pages={93-103}
}
  • ShyTyug Loh, U. Beuscher, +4 authors S. R. Wickramasinghe
  • Published 2009
  • Chemistry
  • Journal of Membrane Science
  • Abstract Normal-flow filtration is used frequently in the biopharmaceutical industry for applications such as sterile filtration of fermentation media, buffers and product proteins. Though the membrane pores are much larger than the product protein, protein fouling of the membrane often leads to a decrease in permeate flux at constant feed pressure. Normal-flow microfiltration experiments were conducted using polytetrafluoroethylene (PTFE) and polyvinylidene fluoride (PVDF) base membranes, PTFE… CONTINUE READING
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