Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.

  title={Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.},
  author={R F Wang and Yin Zheng and Hyun-Seok Kim and Xiaoling Xu and Liu Cao and Tyler Luhasen and M H Lee and Cuiying Xiao and Athanassios Vassilopoulos and Weiping Chen and Kevin Gardner and Yan-gao Man and M -C Hung and Toren Finkel and Chu-xia Deng},
  journal={Molecular cell},
  volume={32 1},
Germline mutations of BRCA1 predispose women to breast and ovarian cancers. However, the downstream mediators of BRCA1 function in tumor suppression remain elusive. We found that human BRCA1-associated breast cancers have lower levels of SIRT1 than their normal controls. We further demonstrated that mammary tumors from Brca1 mutant mice have low levels of Sirt1 and high levels of Survivin, which is reversed by induced expression of Brca1. BRCA1 binds to the SIRT1 promoter and increases SIRT1… CONTINUE READING
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