Interplay Between Superoxide and Nitric Oxide in Aging and Diseases

@article{Afanasev2004InterplayBS,
  title={Interplay Between Superoxide and Nitric Oxide in Aging and Diseases},
  author={Igor B Afanas'ev},
  journal={Biogerontology},
  year={2004},
  volume={5},
  pages={267-270}
}

• Igor B Afanas'ev
• Published 2004 in Biogerontology
• DOI:10.1023/B:BGEN.0000038047.96106.ad

Free radicals, superoxide and nitric oxide, are important signaling molecules, which mediate numerous physiological functions (phagocytosis, vasorelaxation, etc.). However, regulation errors may lead to free-radical-mediated damaging processes in cells and tissues. In this work, the effects of an interplay between superoxide and NO, which may be responsible for the development of aging and diseases, are considered. We are suggesting that the superoxide-mediated proton leak leading to the… CONTINUE READING

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