Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems

@article{Ibekwe2008InterplayBI,
  title={Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems},
  author={Valentine C. Ibekwe and Hala M. Fadda and Emma L. McConnell and Mandeep K. Khela and David F. Evans and Abdul W. Basit},
  journal={Pharmaceutical Research},
  year={2008},
  volume={25},
  pages={1828-1835}
}
Oral pH triggered drug delivery systems, for targeting to the lower gastrointestinal tract, show erratic behaviour in vivo. This study aimed to establish correlations between in situ gastrointestinal pH, transit time or feed status and the disintegration of pH-responsive dosage forms designed to dissolve above pH 7. Tablets (radiolabelled with Technetium 99m) coated with Eudragit S were administered to eight healthy subjects in a three-way crossover study after an overnight fast. Food was… CONTINUE READING

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