Interoceptive conditioning through repeated suppression of morphine-abstinence

@article{Dougherty1979InteroceptiveCT,
  title={Interoceptive conditioning through repeated suppression of morphine-abstinence},
  author={J. Dougherty and D. Miller and A. Wikler},
  journal={The Pavlovian journal of biological science: the official journal of the Pavlovian},
  year={1979},
  volume={14},
  pages={160-169}
}
  • J. Dougherty, D. Miller, A. Wikler
  • Published 1979
  • Psychology, Medicine
  • The Pavlovian journal of biological science: the official journal of the Pavlovian
  • Experimental evaluation of Wikler’s interoceptive conditioning hypothesis of relapse to opioid use in ex-addicts requires a preliminary study of the degree of physical dependence produced by two methods of drug administration. Wistar rats were made physically dependent on morphine by single daily intravenous injections or by a continuous i.v. infusion. Rats received the same total daily dose regardless of administration schedule. The initial daily morphine dose was 20 mg/kg, and was increased… CONTINUE READING

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