Interobserver agreement for estrogen receptor immunohistochemical analysis in breast cancer: a comparison of manual and computer-assisted scoring methods.


Differences in scoring methods for estrogen receptor (ER) immunohistochemistry may cause significant variation in the results. Scoring practices differ within the United States and internationally and include semiquantitative scoring formulas, manual estimations, and computer-assisted techniques. The goal of this study was to determine the rate of… (More)