Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases.

@article{Dong1997InternucleosomalDC,
  title={Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases.},
  author={Zheng Dong and Pothana Saikumar and Joel M. Weinberg and Manjeri A. Venkatachalam},
  journal={The American journal of pathology},
  year={1997},
  volume={151 5},
  pages={1205-13}
}
Autolytic DNA breakdown, detected as smears in electrophoretic gels, is a late event in necrosis. On the other hand, internucleosomal DNA cleavage, visualized as ladders, is thought to be a hallmark of apoptosis. We now report that this specific form of DNA fragmentation also occurs during necrosis and is an early event but appears to be triggered by proteolytic mechanisms significantly different from those documented in apoptosis. Treatment of MDCK cells with a mitochondrial uncoupler and a… CONTINUE READING

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