Internuclear ophthalmoplegia: unusual causes in 114 of 410 patients.

  title={Internuclear ophthalmoplegia: unusual causes in 114 of 410 patients.},
  author={James R Keane},
  journal={Archives of neurology},
  volume={62 5},
Internuclear ophthalmoplegia (INO) is a sign of exquisite localizing value, often due to either multiple sclerosis or infarction. To demonstrate that unusual causes of INO are more common than the 11% reported in previous series, this review considers a case series of 410 inpatients whom I personally examined during a 33-year period. In this series, the cause of INO was infarction in 157 patients (38%), multiple sclerosis in 139 (34%), and unusual causes in 114 (28%). Unusual causes included… CONTINUE READING