Interneurons spark seizure-like activity in the entorhinal cortex

@article{Lvesque2016InterneuronsSS,
  title={Interneurons spark seizure-like activity in the entorhinal cortex},
  author={Maxime L{\'e}vesque and Rochelle Herrington and Shabnam Hamidi and Massimo Avoli},
  journal={Neurobiology of Disease},
  year={2016},
  volume={87},
  pages={91-101}
}
Excessive neuronal synchronization is presumably involved in epileptiform synchronization. However, the respective roles played by interneurons (GABAergic) and principal (glutamatergic) cells during interictal and ictal discharges remain unclear. Here, we employed tetrode wire recordings to establish the involvement of these two cell types in 4-aminopyridine-induced interictal- and low-voltage fast (LVF) onset ictal-like discharges in the rat entorhinal cortex in an in vitro slice preparation… CONTINUE READING

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Low-voltage fast seizures in humans begin with increased interneuron firing.

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CITES METHODS, BACKGROUND & RESULTS

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