Interneurons of the neocortical inhibitory system

  title={Interneurons of the neocortical inhibitory system},
  author={Henry Markram and Maria Toledo-Rodriguez and Yun Wang and Anirudh Gupta and Gilad Silberberg and Caizhi Wu},
  journal={Nature Reviews Neuroscience},
Mammals adapt to a rapidly changing world because of the sophisticated cognitive functions that are supported by the neocortex. The neocortex, which forms almost 80% of the human brain, seems to have arisen from repeated duplication of a stereotypical microcircuit template with subtle specializations for different brain regions and species. The quest to unravel the blueprint of this template started more than a century ago and has revealed an immensely intricate design. The largest obstacle is… 

Generating neuronal diversity in the mammalian cerebral cortex.

The structural blueprint of the neocortex is broadly reviewed and the current classification of its neuronal diversity is discussed, which covers the principles and mechanisms that build neuronal diversity during cortical development and the impact of neuronal class-specific identity in shaping cortical connectivity and function.

The generation of cortical interneurons

Emergent Properties of in silico Synaptic Transmission in a Model of the Rat Neocortical Column

It is demonstrated here that intrinsic morphological diversity confers an invariance to the average synaptic response properties in silico in the local neocortical microcircuit, termed "microcircuit level robustness and invariance".

Formation of Pyramidal Cell Clusters Under Neocortical Balanced Competitive Learning

Natural formation of clustered patterns under inclusion of the two major forms of inhibition existent in neocortical layer 5, those of large basket cells and Martinotti cells are demonstrated.

Behavioral consequences of GABAergic neuronal diversity

Interneuron cell types are fit to function

This perspective emphasizes that the ultimate goal is to dispense with classification criteria and directly define interneuron types by function, and views them as elaborations of a much more finite group of developmentally specified cardinal classes that become further specialized as they mature.

New Interneurons in the Adult Neocortex: Small, Sparse, but Significant?




Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex.

It is suggested that inhibitory synapses could shape the impact of different interneurons according to their specific spatiotemporal patterns of activity and that GABAergic interneuron and synapse diversity may enable combinatorial inhibitory effects in the neocortex.

Stereotypy in neocortical microcircuits

Local circuits in primary visual cortex of the macaque monkey.

The basic laminar organization of excitatory local circuitry in the primary visual cortex of the macaque monkey is similar to that described previously in the cat's visual cortex, but within this basic framework is a more complex organization.

Interneurons unbound

This review brings together recently described properties and emerging principles of interneuron function that indicate a much more complex role for these cells than just providers of inhibition.

Intrinsic firing patterns of diverse neocortical neurons

Anatomical organization of macaque monkey striate visual cortex.

  • J. Lund
  • Biology
    Annual review of neuroscience
  • 1988
I hope that this review of the internal anatomy of the monkey primary visual cortex makes clear the high degree of specialization that exists in each of the cortical laminae and their constituent

Network of GABAergic large basket cells in cat visual cortex (area 18): Implication for lateral disinhibition

The topographical and synaptic relationship between identified GABAergic large basket cells and their immunohistochemically characterized target neurons revealed by parvalbumin‐(PV) and GABA immunostaining in the same material is studied.

Dynamics of population rate codes in ensembles of neocortical neurons.

This work combines theoretical analysis and whole cell recordings to show that encoding signals in the variance of uncorrelated synaptic inputs to a neocortical ensemble enables faithful transmission of graded signals with high temporal resolution.

Synaptic dynamics control the timing of neuronal excitation in the activated neocortical microcircuit

This work proposes that synaptic dynamics choreograph neuronal activity within the neocortical microcircuit in a context‐dependent manner and shows that patterned activity is essential for synaptic dynamics to impose the temporal dispersion of excitatory input.

Circuitry, architecture, and functional dynamics of visual cortex.

It has become increasingly possible to relate the responsive specificity of cortical cells, and the circuitry underlying this specificity, to the perceptual capabilities of the visual system by performing analogous experiments on single cells and in human psychophysics.