Interneurones are not so dormant in temporal lobe epilepsy: a critical reappraisal of the dormant basket cell hypothesis.

@article{Bernard1998InterneuronesAN,
  title={Interneurones are not so dormant in temporal lobe epilepsy: a critical reappraisal of the dormant basket cell hypothesis.},
  author={Christopher Bernard and Monique Esclapez and June C. Hirsch and Yehezkel Ben-Ari},
  journal={Epilepsy research},
  year={1998},
  volume={32 1-2},
  pages={93-103}
}
One axiom at the basis of epilepsy research is that there exists an imbalance between excitation and inhibition. This abnormality can be achieved by an increase of excitation on principal cells, a decreased inhibition (i.e. disinhibition) or both. This review focuses on dysfunction of inhibition, and in particular on the 'dormant basket cell hypothesis'. This hypothesis states that, (1) interneurones are functionally disconnected from excitatory afferents, resulting in hyperexcitability of… CONTINUE READING

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CA1 pyramidal cells in hyperexcitable slices

  • Y. Perez, F. Morin, I. Jutras, C. Beaulieu, Lacaille, J.-C
  • 1996
Highly Influential
5 Excerpts

Changes in EPSCs and IPSCs of hippocampal CA1 interneurons and pyramidal cells in the kainate model of epilepsy

  • F. Morin, C. Beaulieu, Lacaille, J.-C
  • Soc. Neurosci. Abstr
  • 1996
Highly Influential
5 Excerpts

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