Interneuron dysfunction in psychiatric disorders

@article{Marn2012InterneuronDI,
  title={Interneuron dysfunction in psychiatric disorders},
  author={Oscar Mar{\'i}n},
  journal={Nature Reviews Neuroscience},
  year={2012},
  volume={13},
  pages={107-120}
}
  • O. Marín
  • Published 2012
  • Psychology, Medicine
  • Nature Reviews Neuroscience
Schizophrenia, autism and intellectual disabilities are best understood as spectrums of diseases that have broad sets of causes. However, it is becoming evident that these conditions also have overlapping phenotypes and genetics, which is suggestive of common deficits. In this context, the idea that the disruption of inhibitory circuits might be responsible for some of the clinical features of these disorders is gaining support. Recent studies in animal models demonstrate that the molecular… Expand
Neural circuit dysfunction in mouse models of neurodevelopmental disorders
TLDR
Understanding the impact of pathological gene variation in animal models at the level of specific neuronal populations and circuits will likely contribute to orienting human clinical studies in the search for precise disease mechanisms and novel treatments. Expand
Neurobiological bases of autism–epilepsy comorbidity: a focus on excitation/inhibition imbalance
TLDR
The most significant studies supporting hypotheses that an E/I imbalance resulting from neurodevelopmental deficits of multiple origins might represent a common pathogenic mechanism for both autism–epilepsy comorbidity are reviewed. Expand
Investigating Notch 1 contribution to sporadic Alzheimer ’ s disease
Autism spectrum disorders are largely neurodevelopmental disorders with a strong genetic component and are characterized by impairments in social interaction, communication and stereotyped patternsExpand
Cortical interneuron function in autism spectrum condition
TLDR
Finding common physiological mechanisms that underlie neurodevelopmental disorders may lead to novel pharmacological targets and candidates that could improve the cognitive and emotional symptoms associated with ASC. Expand
Developmental timing and critical windows for the treatment of psychiatric disorders
TLDR
This Perspective explores the emerging concept of developmental windows in psychiatric disorders, their relevance for understanding disease progression and their potential for the design of new therapies. Expand
Modeling neurodevelopmental and psychiatric diseases with human iPSCs
  • Zhexing Wen
  • Medicine
  • Journal of neuroscience research
  • 2017
TLDR
Recent progress in the use of human iPSCs for modeling neurodevelopmental and psychiatric disorders and developing novel therapeutic strategies are reviewed, and challenges in this rapidly moving field are discussed. Expand
Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit development
TLDR
It is concluded that "modeling a model", in this case 22q11DS as a model for idiopathic ASD, ADHD and SCZ, as well as other behavioral disorders like anxiety frequently seen in 22q 11DS patients, in genetically engineered mice provides a foundation for understanding the causes and improving diagnosis and therapy for these disorders of cortical circuit development. Expand
Top ten discoveries of the year: Neurodevelopmental disorders
TLDR
Advances in the understanding of the pathogenetic mechanisms reveal a remarkably complex molecular neuropathology involving a myriad of genetic architectures and regulatory elements that will help establish more rigorous genotype-phenotype correlations. Expand
Neurodevelopment, GABA System Dysfunction, and Schizophrenia
TLDR
Evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system is discussed. Expand
The neurobiology of autism spectrum disorders
TLDR
An attempt is made to try and integrate the available evidence, which points to a oligogenetic, multifactorial aetiology that converges in an aberrant micro-organization of the cortex, with abnormal functioning of the synapses and abnormalities in very general physiological pathways (such as inflammatory, immune and redox systems). Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 194 REFERENCES
Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies.
TLDR
A strategy for determining how particular common and core clinical features of the illness are associated with pathophysiology in certain circuits of the cerebral cortex is discussed. Expand
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
TLDR
An improved understanding of the mechanisms by which altered function of NRG1 and ErbB4 contributes to schizophrenia might eventually lead to the development of more effective therapeutics. Expand
The Genetics of Child Psychiatric Disorders: Focus on Autism and Tourette Syndrome
TLDR
Investigations into the genetics of child psychiatric disorders have finally begun to shed light on molecular and cellular mechanisms of psychopathology, and advances in developmental neuroscience are fueling the rapid translation of genetic findings. Expand
Model of autism: increased ratio of excitation/inhibition in key neural systems
TLDR
A model postulates that some forms of autism are caused by an increased ratio of excitation/inhibition in sensory, mnemonic, social and emotional systems and suggests potential therapeutic interventions. Expand
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
TLDR
It is suggested that increased inhibitory synaptic transmission may contribute to human ASDs and that the R451C knockin mice may be a useful model for studying autism-related behaviors. Expand
The Story of Rett Syndrome: From Clinic to Neurobiology
TLDR
To investigate the potential for restoring neuronal function in RTT patients, it is essential to identify MeCP2 targets or modifiers of the phenotype that can be therapeutically modulated. Expand
Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits
TLDR
A mouse knockout of the Cntnap2 gene is characterized, which is strongly associated with ASD and allied neurodevelopmental disorders, and treatment with the FDA-approved drug risperidone ameliorates the targeted repetitive behaviors in the mutant mice. Expand
Neuroligin‐3‐deficient mice: model of a monogenic heritable form of autism with an olfactory deficit
TLDR
The findings show that the NL‐3 knockout mouse represents a useful animal model for understanding pathophysiological events in monogenic heritable ASD and for developing novel treatment strategies in this devastating human disorder. Expand
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
TLDR
It is shown that mice with Shank3 gene deletions exhibit self-injurious repetitive grooming and deficits in social interaction and a critical role for SHANK3 in the normal development of neuronal connectivity is demonstrated. Expand
The mGluR theory of fragile X mental retardation
TLDR
Loss of fragile X mental retardation protein (FMRP), the defect responsible for fragile X syndrome in humans, increases LTD in mouse hippocampus, consistent with the growing evidence that FMRP normally functions as a repressor of translation of specific mRNAs. Expand
...
1
2
3
4
5
...