Interneuron Dysfunction in Syndromic Autism: Recent Advances.

  title={Interneuron Dysfunction in Syndromic Autism: Recent Advances.},
  author={Tomoyuki Takano},
  journal={Developmental neuroscience},
  volume={37 6},
Autism is an extremely heterogeneous disorder, but its frequent cooccurrence with epilepsy leads to speculation that there may be common mechanisms associated with these disorders. Inhibitory interneurons are considered to be the main cellular elements that control hyperexcitability in the brain, and interneuron dysfunction can cause pathological hyperexcitability linked to seizure susceptibility or epilepsy. This review summarizes some of the recent advances that support the relationship… CONTINUE READING