• Biology, Computer Science, Medicine
  • Published in Pharmacological reviews 2001

International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.

@article{Khakh2001InternationalUO,
  title={International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.},
  author={Baljit S Khakh and Geoffrey Burnstock and Colleen S. Kennedy and Brian F. King and Robert Arthur North and Philippe S{\'e}gu{\'e}la and Michael Voigt and Patrick P Humphrey},
  journal={Pharmacological reviews},
  year={2001},
  volume={53 1},
  pages={
          107-18
        }
}
ATP acts as a humoral mediator to control cell function extracellularly. The receptors that mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the transmitter-gated, ion channel P2X receptors. This review describes the structure, distribution, function, and ligand recognition characteristics of P2X receptors, which comprise seven distinct subunits that can function as both homo- and hetero- polymers. The pharmacology of P2X receptors is complicated by marked… CONTINUE READING

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