International trial of the Edmonton protocol for islet transplantation.

  title={International trial of the Edmonton protocol for islet transplantation.},
  author={A M James Shapiro and Camillo Ricordi and Bernhard J. Hering and Hugh Auchincloss and Robert Lindblad and R. Paul Robertson and Antonio Secchi and Mathias D. Brendel and Thierry Berney and Daniel C. Brennan and Enrico Cagliero and Rodolfo Alejandro and Edmond A. Ryan and Barbara S DiMercurio and Philippe Morel and Kenneth S. Polonsky and J Reems and Reinhard Georg Bretzel and Federico Bertuzzi and Tatiana Froud and Raja Kandaswamy and David E. R. Sutherland and George S. Eisenbarth and Miriam Segal and Jutta K. Preiksaitis and Gregory S. Korbutt and Franca Benedicty Barton and Lisa Viviano and Vicki Seyfert-Margolis and Jeffrey A Bluestone and Jonathan Rt Lakey},
  journal={The New England journal of medicine},
  volume={355 13},
BACKGROUND Islet transplantation offers the potential to improve glycemic control in a subgroup of patients with type 1 diabetes mellitus who are disabled by refractory hypoglycemia. We conducted an international, multicenter trial to explore the feasibility and reproducibility of islet transplantation with the use of a single common protocol (the Edmonton protocol). METHODS We enrolled 36 subjects with type 1 diabetes mellitus, who underwent islet transplantation at nine international sites… CONTINUE READING
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