International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*

@article{Goldstein2005InternationalPS,
  title={International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*},
  author={Brahm Goldstein and Brett P. Giroir and Adrienne G. Randolph},
  journal={Pediatric Critical Care Medicine},
  year={2005},
  volume={6},
  pages={2-8}
}
Objective: Although general definitions of the sepsis continuum have been published for adults, no such work has been done for the pediatric population. Physiologic and laboratory variables used to define the systemic inflammatory response syndrome (SIRS) and organ dysfunction require modification for the developmental stages of children. An international panel of 20 experts in sepsis and clinical research from five countries (Canada, France, Netherlands, United Kingdom, and United States) was… Expand
Pediatric definitions for sepsis: it's about time!
  • M. Parker
  • Medicine
  • Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2005
TLDR
The International Pediatric Sepsis Conference definitions for sepsis and organ failure in children are reported, and this international group is to be congratulated for providing much-needed standardization of definitions forSepsis. Expand
Pediatric Sepsis Definition—A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce
TLDR
A systematic review of factors, clinical criteria, and illness severity scores that may be used to identify children with infection who have or are at high risk of developing sepsis-associated organ dysfunction and/or progressing to multiple organ dysfunction or death is conducted. Expand
Time for a Neonatal-Specific Consensus Definition for Sepsis
TLDR
Pediatric sepsis criteria are not accurate for term neonates and have not been examined in preterm neonates for whom the developmental stage influences aberrations associated with host immune response, so specific consensus definitions are needed. Expand
Comparison of International Pediatric Sepsis Consensus Conference Versus Sepsis-3 Definitions for Children Presenting With Septic Shock to a Tertiary Care Center in India: A Retrospective Study*
TLDR
Less than half of children with septic shock identified by International Pediatric Sepsis Consensus Conference definitions were observed to fulfill the criteria for shock as per “Sepsis-3” definitions, which raises questions on the appropriateness of using this definition for diagnosis of septicshock in children. Expand
Systemic Inflammatory Response Syndrome (SIRS) and Sepsis — An Ever-evolving Paradigm
TLDR
The hospital based descriptive point prevalence study evaluated the clinical and demographic profile of children, admitted to the hospital and confirmed the fact that childhood pneumonia is the most common cause of pediatric severe sepsis worldwide. Expand
Challenges in developing a consensus definition of neonatal sepsis
TLDR
The need for a consensus definition of neonatal sepsis and the challenges that this task poses is highlighted, and recent progress in adults with publication of Sepsis-3 provides guidance on how a consensus definitions and screening criteria for sepsi could be produced in neonatology. Expand
Defining Pediatric Sepsis.
TLDR
The present definition of sepsis is of limited benefit in many parts of Asia and sub-Saharan Africa, and many health care facilities in low and middle-income countries do not have the resources to perform white blood cell counts (a requirement for diagnosing SIRS); hence, the present definition is oflimited benefit. Expand
Clinical Update in Pediatric Sepsis: Focus on Children With Pre-Existing Heart Disease.
TLDR
The authors examine the evolving epidemiology of pediatric sepsis, including the subset of patients with underlying heart disease; contrast pediatric and adult sepsIS; review the latest hemodynamic guidelines for management of pediatric Sepsis and their application to children withHeart disease; discuss the role of mechanical circulatory support; and review key aspects of anesthetic management for children with sepsi. Expand
Pediatric sepsis
TLDR
Adherence to current and emerging practice guidelines will require that protocolized care pathways become a commonplace, and distinct physiology demands more prospective pediatric trials to tailor management to the pediatric population. Expand
Diagnostic Challenges and Laboratory Considerations for Pediatric Sepsis.
TLDR
A major hurdle is the lack of validated clinical criteria for classification of pediatric sepsis, which is necessary for the development of well-designed studies that can assess the clinical impact of these emerging biomarkers. Expand
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