International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*

  title={International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*},
  author={Brahm Goldstein and Brett P. Giroir and Adrienne G. Randolph},
  journal={Pediatric Critical Care Medicine},
Objective: Although general definitions of the sepsis continuum have been published for adults, no such work has been done for the pediatric population. Physiologic and laboratory variables used to define the systemic inflammatory response syndrome (SIRS) and organ dysfunction require modification for the developmental stages of children. An international panel of 20 experts in sepsis and clinical research from five countries (Canada, France, Netherlands, United Kingdom, and United States) was… 
Pediatric definitions for sepsis: it's about time!
  • M. Parker
  • Medicine
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2005
The International Pediatric Sepsis Conference definitions for sepsis and organ failure in children are reported, and this international group is to be congratulated for providing much-needed standardization of definitions forSepsis.
Pediatric Sepsis Definition—A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce
A systematic review of factors, clinical criteria, and illness severity scores that may be used to identify children with infection who have or are at high risk of developing sepsis-associated organ dysfunction and/or progressing to multiple organ dysfunction or death is conducted.
The Current and Future State of Pediatric Sepsis Definitions: An International Survey.
The 2005 consensus definitions were perceived to be the most useful for sepsis recognition, while Sepsis-3 definitions were stated as more useful for benchmarking, disease classification, enrollment into trials, and prognostication.
Time for a Neonatal-Specific Consensus Definition for Sepsis
Pediatric sepsis criteria are not accurate for term neonates and have not been examined in preterm neonates for whom the developmental stage influences aberrations associated with host immune response, so specific consensus definitions are needed.
Comparison of International Pediatric Sepsis Consensus Conference Versus Sepsis-3 Definitions for Children Presenting With Septic Shock to a Tertiary Care Center in India: A Retrospective Study*
Less than half of children with septic shock identified by International Pediatric Sepsis Consensus Conference definitions were observed to fulfill the criteria for shock as per “Sepsis-3” definitions, which raises questions on the appropriateness of using this definition for diagnosis of septicshock in children.
Challenges in developing a consensus definition of neonatal sepsis
The need for a consensus definition of neonatal sepsis and the challenges that this task poses is highlighted, and recent progress in adults with publication of Sepsis-3 provides guidance on how a consensus definitions and screening criteria for sepsi could be produced in neonatology.
Systemic Inflammatory Response Syndrome (SIRS) and Sepsis — An Ever-evolving Paradigm
The hospital based descriptive point prevalence study evaluated the clinical and demographic profile of children, admitted to the hospital and confirmed the fact that childhood pneumonia is the most common cause of pediatric severe sepsis worldwide.
Defining Pediatric Sepsis.
The present definition of sepsis is of limited benefit in many parts of Asia and sub-Saharan Africa, and many health care facilities in low and middle-income countries do not have the resources to perform white blood cell counts (a requirement for diagnosing SIRS); hence, the present definition is oflimited benefit.
Clinical Update in Pediatric Sepsis: Focus on Children With Pre-Existing Heart Disease.
The authors examine the evolving epidemiology of pediatric sepsis, including the subset of patients with underlying heart disease; contrast pediatric and adult sepsIS; review the latest hemodynamic guidelines for management of pediatric Sepsis and their application to children withHeart disease; discuss the role of mechanical circulatory support; and review key aspects of anesthetic management for children with sepsi.
Criteria for Pediatric Sepsis—A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce*
Strong associations of several markers of organ dysfunction with the outcomes of interest among infected and septic children support their inclusion in the data validation phase of the Pediatric Sepsis Definition Taskforce.


[Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock].
American College of Critical Care Medicine adult guide lines for hemodynamic support of septic shock have little application to the management of pediatric or neonatal septicaemia and vasopressors can be more important contributors to adult survival.
The epidemiology of severe sepsis in children in the United States.
Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources, and the mean length of stay and cost were 31 days and $40,600, respectively.
The Pediatric Multiple Organ Dysfunction Score (P-MODS): Development and validation of an objective scale to measure the severity of multiple organ dysfunction in critically ill children*
With further study and validation across many centers, it is likely that P-MODS could function as a quantitative, clinically relevant surrogate outcome measure for future therapeutic trials.
Measurements of total plasma nitrite and nitrate in pediatric patients with the systemic inflammatory response syndrome.
The data suggest that increased plasma nitrite/nitrate concentrations are the standard for identifying patients with inflammation in the pediatric ICU, as defined by criteria based on physician diagnosis.
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
A hypothetical model for staging sepsis is presented, which, in the future, may better characterize the syndrome on the basis of predisposing factors and premorbid conditions, the nature of the underlying infection, the characteristics of the host response, and the extent of the resultant organ dysfunction.
The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.
The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and
Procalcitonin is persistently increased among children with poor outcome from bacterial sepsis*
  • Y. Han, L. Doughty, Danny Kofos, H. Sasser, J. Carcillo
  • Medicine, Biology
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2003
Procalcitonin concentrations were persistently increased over time among patients with bacterial sepsis who had persistent multiple organ failure and who died and to characterize any mechanistic role that procalCitonin might play in the development of bacterial Sepsis-induced multiple organs failure and mortality.
Development of a Pediatric Multiple Organ Dysfunction Score
The PELOD system was more discriminant than the PEMOD system and had the advantage of taking into ac count both the relative severities among ODs and the degree of severity of each OD.