International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*

@article{Goldstein2005InternationalPS,
  title={International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*},
  author={Brahm Goldstein and Brett P. Giroir and Adrienne G. Randolph},
  journal={Pediatric Critical Care Medicine},
  year={2005},
  volume={6},
  pages={2-8}
}
Objective: Although general definitions of the sepsis continuum have been published for adults, no such work has been done for the pediatric population. Physiologic and laboratory variables used to define the systemic inflammatory response syndrome (SIRS) and organ dysfunction require modification for the developmental stages of children. An international panel of 20 experts in sepsis and clinical research from five countries (Canada, France, Netherlands, United Kingdom, and United States) was… 
Pediatric definitions for sepsis: it's about time!
  • M. Parker
  • Medicine
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2005
TLDR
The International Pediatric Sepsis Conference definitions for sepsis and organ failure in children are reported, and this international group is to be congratulated for providing much-needed standardization of definitions forSepsis.
Pediatric Sepsis Definition—A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce
TLDR
A systematic review of factors, clinical criteria, and illness severity scores that may be used to identify children with infection who have or are at high risk of developing sepsis-associated organ dysfunction and/or progressing to multiple organ dysfunction or death is conducted.
The Current and Future State of Pediatric Sepsis Definitions: An International Survey.
TLDR
The 2005 consensus definitions were perceived to be the most useful for sepsis recognition, while Sepsis-3 definitions were stated as more useful for benchmarking, disease classification, enrollment into trials, and prognostication.
Time for a Neonatal-Specific Consensus Definition for Sepsis
TLDR
Pediatric sepsis criteria are not accurate for term neonates and have not been examined in preterm neonates for whom the developmental stage influences aberrations associated with host immune response, so specific consensus definitions are needed.
Comparison of International Pediatric Sepsis Consensus Conference Versus Sepsis-3 Definitions for Children Presenting With Septic Shock to a Tertiary Care Center in India: A Retrospective Study*
TLDR
Less than half of children with septic shock identified by International Pediatric Sepsis Consensus Conference definitions were observed to fulfill the criteria for shock as per “Sepsis-3” definitions, which raises questions on the appropriateness of using this definition for diagnosis of septicshock in children.
Challenges in developing a consensus definition of neonatal sepsis
TLDR
The need for a consensus definition of neonatal sepsis and the challenges that this task poses is highlighted, and recent progress in adults with publication of Sepsis-3 provides guidance on how a consensus definitions and screening criteria for sepsi could be produced in neonatology.
Systemic Inflammatory Response Syndrome (SIRS) and Sepsis — An Ever-evolving Paradigm
TLDR
The hospital based descriptive point prevalence study evaluated the clinical and demographic profile of children, admitted to the hospital and confirmed the fact that childhood pneumonia is the most common cause of pediatric severe sepsis worldwide.
Defining Pediatric Sepsis.
TLDR
The present definition of sepsis is of limited benefit in many parts of Asia and sub-Saharan Africa, and many health care facilities in low and middle-income countries do not have the resources to perform white blood cell counts (a requirement for diagnosing SIRS); hence, the present definition is oflimited benefit.
Clinical Update in Pediatric Sepsis: Focus on Children With Pre-Existing Heart Disease.
TLDR
The authors examine the evolving epidemiology of pediatric sepsis, including the subset of patients with underlying heart disease; contrast pediatric and adult sepsIS; review the latest hemodynamic guidelines for management of pediatric Sepsis and their application to children withHeart disease; discuss the role of mechanical circulatory support; and review key aspects of anesthetic management for children with sepsi.
Criteria for Pediatric Sepsis—A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce*
TLDR
Strong associations of several markers of organ dysfunction with the outcomes of interest among infected and septic children support their inclusion in the data validation phase of the Pediatric Sepsis Definition Taskforce.
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