International cohort analysis of the antiviral activities of zidovudine and tenofovir in the presence of the K65R mutation in reverse transcriptase.

@article{Grant2010InternationalCA,
  title={International cohort analysis of the antiviral activities of zidovudine and tenofovir in the presence of the K65R mutation in reverse transcriptase.},
  author={Philip M. Grant and J. Taylor and Andrew B Nevins and Vincent Calvez and Anne-genevi{\`e}ve Marcelin and Marc Wirden and Andrew R. Zolopa},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 4},
  pages={1520-5}
}
A K65R mutation in HIV-1 reverse transcriptase can occur with the failure of tenofovir-, didanosine-, abacavir-, and, in some cases, stavudine-containing regimens and leads to reduced phenotypic susceptibility to these drugs and hypersusceptibility to zidovudine, but its clinical impact is poorly described. We identified isolates with the K65R mutation within the Stanford Resistance Database and a French cohort for which subsequent treatment and virological response data were available. The… CONTINUE READING

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