• Corpus ID: 41443597

International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function.

@article{Bowery2002InternationalUO,
  title={International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function.},
  author={Norman G. Bowery and Bernhard Bettler and Wolfgang Froestl and Joel P. Gallagher and Fiona H Marshall and Maurizio Raiteri and Tom I. Bonner and Sam J. Enna},
  journal={Pharmacological reviews},
  year={2002},
  volume={54 2},
  pages={
          247-64
        }
}
The gamma-aminobutyric acid(B) (GABA(B)) receptor was first demonstrated on presynaptic terminals where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter release by suppressing neuronal Ca(2+) conductance. Subsequent studies showed the presence of the receptor on postsynaptic neurones where activation produces an increase in membrane K(+) conductance and associated neuronal hyperpolarization. (-)-Baclofen is a highly selective agonist for GABA(B) receptors… 

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