International Union of Pharmacology. XXXIII. Mammalian γ-Aminobutyric AcidB Receptors: Structure and Function

@article{Bowery2002InternationalUO,
  title={International Union of Pharmacology. XXXIII. Mammalian $\gamma$-Aminobutyric AcidB Receptors: Structure and Function},
  author={N. Bowery and B. Bettler and W. Froestl and J. Gallagher and F. Marshall and M. Raiteri and T. Bonner and S. Enna},
  journal={Pharmacological Reviews},
  year={2002},
  volume={54},
  pages={247 - 264}
}
The γ-aminobutyric acidB(GABAB) receptor was first demonstrated on presynaptic terminals where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter release by suppressing neuronal Ca2+ conductance. Subsequent studies showed the presence of the receptor on postsynaptic neurones where activation produces an increase in membrane K+ conductance and associated neuronal hyperpolarization. (−)-Baclofen is a highly selective agonist for GABAB receptors, whereas the… Expand

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