International Union of Pharmacology. XXXIII. Mammalian γ-Aminobutyric AcidB Receptors: Structure and Function

  title={International Union of Pharmacology. XXXIII. Mammalian $\gamma$-Aminobutyric AcidB Receptors: Structure and Function},
  author={Norman G. Bowery and Bernhard Bettler and Wolfgang Froestl and Joel P. Gallagher and Fiona H Marshall and Maurizio Raiteri and Tom I. Bonner and Sam J. Enna},
  journal={Pharmacological Reviews},
  pages={247 - 264}
The γ-aminobutyric acidB(GABAB) receptor was first demonstrated on presynaptic terminals where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter release by suppressing neuronal Ca2+ conductance. Subsequent studies showed the presence of the receptor on postsynaptic neurones where activation produces an increase in membrane K+ conductance and associated neuronal hyperpolarization. (−)-Baclofen is a highly selective agonist for GABAB receptors, whereas the… 

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