International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors

  title={International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors},
  author={D. Poyner and P. Sexton and I. Marshall and D. M. Smith and R. Quirion and W. Born and R. Muff and J. Fischer and S. Foord},
  journal={Pharmacological Reviews},
  pages={233 - 246}
  • D. Poyner, P. Sexton, +6 authors S. Foord
  • Published 2002
  • Medicine, Chemistry
  • Pharmacological Reviews
  • The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related peptides (CGRPs), and adrenomedullin. The first calcitonin receptor was cloned in 1991. Its pharmacology is complicated by the existence of several splice variants. The receptors for the other members the family are made up of subunits. The calcitonin-like receptor (CL receptor) requires a single transmembrane domain protein, termed receptor activity modifying protein, RAMP1, to function as a CGRP… CONTINUE READING
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