International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors

@article{Howlett2002InternationalUO,
  title={International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors},
  author={A. Howlett and F. Barth and T. Bonner and G. Cabral and P. Casellas and W. Devane and C. Felder and M. Herkenham and K. Mackie and B. Martin and R. Mechoulam and R. Pertwee},
  journal={Pharmacological Reviews},
  year={2002},
  volume={54},
  pages={161 - 202}
}
Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD:1:CB1:), cloned in 1990, and CB2(2.1:CBD:2:CB2:), cloned in 1993. Distinction between these receptors is based on differences in their predicted amino acid sequence, signaling mechanisms, tissue distribution, and sensitivity to certain potent agonists and antagonists that show marked selectivity for one or the other receptor type. Cannabinoid receptors CB1 and CB2 exhibit 48% amino acid sequence identity. Both receptor… Expand
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