International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels

@article{Catterall2005InternationalUO,
  title={International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels},
  author={William A. Catterall and Edward Perez-Reyes and Terrance P Snutch and Joerg Striessnig},
  journal={Pharmacological Reviews},
  year={2005},
  volume={57},
  pages={411 - 425}
}
The family of voltage-gated calcium channels serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events. There are 10 members of the voltage-gated calcium channel family that have been characterized in mammals, and they serve distinct roles in cellular signal transduction. This article presents the molecular relationships and physiological functions of these calcium channel proteins and… Expand
Trafficking and stability of voltage-gated calcium channels
TLDR
An overview about the current state of knowledge of calcium channel trafficking to the cell membrane, and of the mechanisms regulating the stability and internalization of this important ion channel family is provided. Expand
L-Type Calcium Channels: Structure and Functions
Voltage-gated calcium channels (VGCCs) manage the electrical signaling of cells by allowing the selective-diffusion of calcium ions in response to the changes in the cellular membrane potential.Expand
Voltage-gated calcium channels.
  • W. Catterall
  • Biology, Medicine
  • Cold Spring Harbor perspectives in biology
  • 2011
TLDR
The molecular relationships and physiological functions of these voltage-gated Ca(2+) channel proteins are presented and information on their molecular, genetic, physiological, and pharmacological properties is provided. Expand
Voltage-Gated Sodium Channels: Biophysics, Pharmacology, and Related Channelopathies
TLDR
The structure, function, and biophysical properties of VGSC as well as their pharmacology and associated channelopathies are outlined and some of the recent advances in this field are highlighted. Expand
Molecular basis of inherited calcium channelopathies: role of mutations in pore-forming subunits
TLDR
Current understanding of the mutations underlying channelopathies involving the voltage-gated calcium channel alpha subunits in humans and other species is document. Expand
Chapter 7 L-Type Calcium Channels : Structure and Functions
Voltage-gated calcium channels (VGCCs) manage the electrical signaling of cells by allowing the selective-diffusion of calcium ions in response to the changes in the cellular membrane potential.Expand
Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties
TLDR
It is shown for the first time, to the knowledge, that Cav3.2 channels are highly phosphorylated in the mammalian brain and phosphorylation is established as an important mechanism involved in the dynamic regulation of Cav 3.2 channel gating properties. Expand
Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels
TLDR
The different classes of sodium and calcium channel drugs are outlined, studies that have identified amino acid residues that are required for their binding and therapeutic actions are reviewed, and how the analogs of those key amino Acid residues may form drug-binding sites in three-dimensional models derived from bacterial channels are illustrated. Expand
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential
TLDR
This review describes how use-dependent blockers of the different isoforms could selectively block calcium channels in particular pathologies, such as nociceptive neurons in pain states or in epileptic brain circuits, and describes how selectivity for different subtypes of calcium channels may be achieved in the future. Expand
Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective.
TLDR
Structural and functional data from prokaryotic and eukaryotic channels are explored and compared to infer the effects of evolution on sodium channel structure and function. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 377 REFERENCES
Structure and function of voltage-gated ion channels
TLDR
Recent work locating the structural elements that are responsible for these three basic functions of the voltage-gated ion channels is reviewed and reveals strong functional analogies among the different ion channels. Expand
Calcium channelopathies: voltage-gated calcium channels.
TLDR
The data illustrate that small perturbations in voltage-gated calcium channel function induced by genetic alterations can affect a wide variety of mammalian developmental, physiological and behavioral functions and point towards new therapeutic strategies for developing highly selective calcium channel antagonists. Expand
Pharmacology, Structure and Function of Cardiac L-Type Ca2+ Channels
  • J. Striessnig
  • Biology, Medicine
  • Cellular Physiology and Biochemistry
  • 1999
TLDR
Alterations in Ca2+ channel activity under pathological conditions such as in heart failure or during ischemia could provide new clues for the development of drugs to treat cardiovascular diseases. Expand
Voltage-dependent calcium channels: from structure to function.
TLDR
Site-directed mutagenesis has identified sites on voltage-activated calcium channels, which interact specifically with other proteins, inhibitors and ions, which are an essential part of many excitable and non-excitable mammalian cells. Expand
Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.
TLDR
The results of recent studies that define the receptor sites and mechanisms of action of these diverse toxins are reviewed here. Expand
L‐type voltage‐gated calcium channels: understanding function through structure
TLDR
This article considers each of the VGCC structures in terms of similarities and differences with an emphasis upon translation of data into a biological context. Expand
Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin
TLDR
A new scorpion toxin is identified that binds to the α1G T-type calcium channel with high affinity and inhibits the channel by modifying voltage-dependent gating, and will facilitate characterization of the subunit composition of T- type calcium channels and help determine their involvement in electrical and biochemical signaling. Expand
Nomenclature of Voltage-Gated Sodium Channels
TLDR
The present alphabetical nomenclature does not reveal the structural relationships among the α1 subunits of Ca2+ channels, but it is apparent that these two alphabeticals will overlap at α1L, which may not mediate an L-type Ca2- current and therefore may create confusion. Expand
Nomenclature of Voltage-Gated Calcium Channels
TLDR
A new nomen-ties of the channel complex, the pharmacological and clature of voltage-gated Ca 2ϩ channels, which electrophysiological diversity of Ca 2 ϩ channels arises is more systematic and mimics the well-defined K ϩ primarily from the existence of multiple forms of ␣ 1 sub-channel nomenclature. Expand
Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms.
TLDR
The structural (sequence) similarities between the cardiac and nerve channels are examined and what is known about the relationship of structure to function for voltage-dependent Na channels in general and for the cardiac Na channel in particular are considered. Expand
...
1
2
3
4
5
...