International Union of Pharmacology. XLVI. G Protein-Coupled Receptor List

@article{Foord2005InternationalUO,
  title={International Union of Pharmacology. XLVI. G Protein-Coupled Receptor List},
  author={Steven M. Foord and Tom I. Bonner and Richard R. Neubig and Edward M. Rosser and Jean-Philippe Pin and Anthony P. Davenport and Michael Spedding and Anthony J. Harmar},
  journal={Pharmacological Reviews},
  year={2005},
  volume={57},
  pages={279 - 288}
}
NC-IUPHAR (International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification) and its subcommittees provide authoritative reports on the nomenclature and pharmacology of G protein-coupled receptors (GPCRs) that summarize their structure, pharmacology, and roles in physiology and pathology. These reports are published in Pharmacological Reviews (http://www.iuphar.org/nciuphar_arti.html) and through the International Union of Pharmacology (IUPHAR) Receptor Database… 
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References

SHOWING 1-10 OF 23 REFERENCES
The G protein-coupled receptor repertoires of human and mouse
TLDR
The repertoire of GPCRs for endogenous ligands consists of 367 receptors in humans and 392 in mice, including 26 human and 83 mouse GPCR not previously identified, revealing an unexpected level of orthology.
Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands
TLDR
The authors' trees show the overall relationship of 277 GPCRs with emphasis on orphan receptors, and may prove valuable for identification of the natural ligands of orphan receptors as their relation to receptors with known ligands becomes more evident.
International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors
TLDR
A review of the calcitonin family of peptides aims to reconcile what is observed when the receptors are reconstituted in vitro with the properties they show in native cells and tissues.
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.
TLDR
This study represents the first overall map of the GPCR sequences in a single mammalian genome and shows several common structural features indicating that the human GPCRs in the GRAFS families share a common ancestor.
Evidence for kinship between diverse G-protein coupled receptors.
Discovery of a null mutation in a human trace amine receptor gene.
Molecular tinkering of G protein‐coupled receptors: an evolutionary success
TLDR
Indirect studies have led to a useful model of a common ‘central core’, composed of seven transmembrane helical domains, and its structural modifications during activation of G protein‐coupled receptors.
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
This issue of Pharmacological Reviews includes a new venture in the collaboration between the International Union of Pharmacology (IUPHAR) and the American Society for Pharmacology and Experimental…
The human olfactory receptor repertoire
TLDR
The identification and cloning of all functional human odorant receptor genes is an important initial step in understanding receptor-ligand specificity and combinatorial encoding of odorant stimuli in human olfaction.
No Ligand Binding in the GB2 Subunit of the GABABReceptor Is Required for Activation and Allosteric Interaction between the Subunits
TLDR
The GABAB receptor is further refined and the putative-binding site in the VFTM of GB2 is characterized, indicating that ligand binding in the GB2 V FTM is not required for activation and most residues of the binding pocket are conserved from Caenorhabditis elegans to human, no such conservation is observed in GB2.
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