International Union of Pharmacology. LXVI. Orphan Nuclear Receptors

@article{Benoit2006InternationalUO,
  title={International Union of Pharmacology. LXVI. Orphan Nuclear Receptors},
  author={G{\'e}rard Benoit and Austin John Cooney and Vincent Gigu{\`e}re and Holly A. Ingraham and Mitch Lazar and George E. O. Muscat and Thomas Perlmann and Jean-Paul Renaud and John W. R. Schwabe and Frances M. Sladek and Ming-Jer Tsai and Vincent Laudet},
  journal={Pharmacological Reviews},
  year={2006},
  volume={58},
  pages={798 - 836}
}
Half of the members of the nuclear receptors superfamily are so-called “orphan” receptors because the identity of their ligand, if any, is unknown. Because of their important biological roles, the study of orphan receptors has attracted much attention recently and has resulted in rapid advances that have helped in the discovery of novel signaling pathways. In this review we present the main features of orphan receptors, discuss the structure of their ligand-binding domains and their biological… Expand
The orphan nuclear receptors at their 25-year reunion.
TLDR
A compendium of so-called orphan receptors, identified based on their similarity to steroid hormone receptors but without a known ligand, focuses on what has been learned about their modes of action, physiological functions, and therapeutic promise. Expand
Orphan Nuclear Receptors as Targets for Drug Development
TLDR
This review ofphan nuclear receptors highlights their roles in several physiologic and pathophysiologic actions and demonstrates how their functions can be exploited for the successful development of newer drugs. Expand
ROR nuclear receptors: structures, related diseases, and drug discovery
TLDR
The structural basis, disease relevance, strategies for ligand identification, and current status of development of therapeutic ligands for RORs are reviewed. Expand
The orphan nuclear receptors in cancer and diabetes
  • H. Ranhotra
  • Biology, Medicine
  • Journal of receptor and signal transduction research
  • 2013
TLDR
The current status about the interplay between select ONRs in cancer and diabetes is discussed and results obtained are encouraging and interesting and shows a number of ONRs does modulate several patho-physiological conditions such as cancer andabetes. Expand
The emerging roles of orphan nuclear receptors in prostate cancer.
TLDR
It is proposed that a better understanding of the mechanism of actions of these orphan NRs in prostate gland or prostate cancer could help to evaluate their potential value as therapeutic targets for prostate cancer. Expand
Therapeutic potential of nuclear receptors
TLDR
This review provides an overview on the molecular classification and disease relevance of NRs, as well as on recent advances in pharmacologic (pre-clinical targeting approaches and patent applications, using various databases and websites. Expand
The mammalian orphan nuclear receptors: orphans as cellular guardians
  • H. Ranhotra
  • Biology, Medicine
  • Journal of receptor and signal transduction research
  • 2011
TLDR
In mammals, ONRs exhibit great functional diversity and majority of them are expressed in a tissue-specific fashion, and hence they may be potential candidates for therapeutic drug targeting in the future. Expand
Nuclear Hormone Receptor Medicinal Chemistry
This chapter will be focused on recent advances in the medicinal chemistry of agonist, antagonist, and modulator ligands of selected nuclear hormone receptors (NHRs) that are of special interest inExpand
Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor
TLDR
AIMS is used to establish a general method to identify true endogenous ligands for nuclear receptors (and other lipid binding proteins), independent of transcriptional function, and to track in vivo receptor occupancy under physiologically relevant conditions. Expand
Therapeutic potential of Liver Receptor Homolog-1 modulators
TLDR
Synthetic ligands for LRH-1 have been identified and such compounds may yield useful therapeutics for a range of pathologic conditions associated with aberrant expression and activity of LRh-1. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 661 REFERENCES
Digging deep into the pockets of orphan nuclear receptors: insights from structural studies.
TLDR
It is now evident that some orphan receptors lack the capacity for ligand binding, which suggests that they are regulated by alternative, ligand-independent mechanisms. Expand
Physiological function of the orphans GCNF and COUP-TF
TLDR
Progress made in understanding the roles of the orphans GCNF and the COUP-TFs with the use of gene knockouts is reviewed. Expand
Orphan nuclear receptors: an emerging family of metabolic regulators.
TLDR
Current knowledge suggests that many orphan nuclear receptors transduce intracellular signals essential for the regulation of basic cellular functions and modulate gene expression in response to environmental stimuli and metabolic demands. Expand
The RXR heterodimers and orphan receptors
TLDR
The historical links between the steroid and nonsteroid receptor signaling systems are established, the explosive development of the retinoid X receptor (RXR) heterodimer and orphan receptor family is charted, the impact of these discoveries on the authors' understanding of the mechanisms of hormonal signaling is explained, and emerging issues and implications are presented. Expand
Orphan nuclear receptors: shifting endocrinology into reverse.
TLDR
A "reverse endocrinology" strategy has resulted in the discovery of unanticipated nuclear signaling pathways for retinoids, fatty acids, eicosanoids, and steroids with important physiological and pharmacological ramifications. Expand
Orphan nuclear receptors: from new ligand discovery technologies to novel signaling pathways.
TLDR
How biochemical assays have been used to identify naturally occurring and synthetic ligands for the liver X receptor, farnesoid X receptor and estrogen receptor-related receptor subfamilies of orphans, the use of these ligands in the discovery of novel biological signaling pathways and the potential clinical implications of these findings are reviewed. Expand
Role reversal: new insights from new ligands for the xenobiotic receptor CAR
TLDR
Both inverse agonists and conventional agonist ligands have been identified for the xenobiotic receptor constitutive androstane receptor (CAR), a constitutive activator of transcription in the absence of ligands. Expand
Nuclear Receptors
  • E. Milgrom
  • Medicine
  • Methods in Molecular Biology
  • 2019
Nuclear receptors form a superfamily of transcriptional regulators including both classical hormone receptors and orphan receptors. The functional anatomy of the receptors is described as well asExpand
Ligand binding and nuclear receptor evolution
TLDR
Arguments from phylogenetic, functional and structural studies are presented that support the hypothesis that there have been several independent gains of ligand‐binding ability of nuclear receptors during metazoan evolution. Expand
Bioinformatics of nuclear receptors.
TLDR
The future lies in ‘‘postgenomic’’ bioinformatics: through the integration of experimental data into bioinformatic bases and the analysis of nonannotated sequences. Expand
...
1
2
3
4
5
...