International Union of Pharmacology. LXVI. Orphan nuclear receptors.

@article{Benoit2006InternationalUO,
  title={International Union of Pharmacology. LXVI. Orphan nuclear receptors.},
  author={Gerard R Benoit and Austin John Cooney and Vincent Gigu{\`e}re and Holly A. Ingraham and Mitch Lazar and George E. O. Muscat and Thomas Perlmann and Jean-Paul Renaud and John W R Schwabe and Frances M. Sladek and Ming-jer Tsai and Vincent Laudet},
  journal={Pharmacological reviews},
  year={2006},
  volume={58 4},
  pages={
          798-836
        }
}
Half of the members of the nuclear receptors superfamily are so-called "orphan" receptors because the identity of their ligand, if any, is unknown. Because of their important biological roles, the study of orphan receptors has attracted much attention recently and has resulted in rapid advances that have helped in the discovery of novel signaling pathways. In this review we present the main features of orphan receptors, discuss the structure of their ligand-binding domains and their biological… CONTINUE READING

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